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:: Overview :: Precautions :: Side Effects Search results last updated: 9/17/2008

Generic & Brand Name : Source: (MedicineNet)

Brand Name : Zaroxolyn; Diulo; Mykrox
Generic Name : metolazone

Overview (Source: MedicineNet)
Metolazone is a diuretic ("water pill") used in the treatment of high blood pressure and fluid accumulation. It works by blocking salt and fluid retention in the kidneys, thereby increasing urinary output of salt and water (diuresis). Although it is not a true thiazide, metolazone is chemically related to the thiazide class of diuretics, and works in a similar manner. Zaroxolyn is the original formulation of metolazone, and Diulo is similar. The absorption of these two drugs is relatively incomplete. Mykrox has more complete absorption. Therefore, less Mykrox needs to be given to have the same effects as a larger dose of Zaroxolyn or Diulo. Metolazone was approved by the FDA in 1973. ...
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Precautions (Source: MedLinePlus)
Before taking metolazone, tell your doctor and pharmacist if you are allergic to metolazone, sulfa drugs, or any other drugs. tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially other medications for high blood pressure, anti-inflammatory medications such as ibuprofen (Motrin, Nuprin) or naproxen (Aleve), corticosteroids (e.g., prednisone), lithium (Eskalith, Lithobid), medications for diabetes, probenecid (Benemid), and vitamins. If you also are taking cholestyramine or colestipol, take it at least 1 hour after metolazone. tell your doctor if you have or have ever had diabetes, gout, or kidney, liver, thyroid, or parathyroid disease. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking metolazone, call your doctor immediately. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking metolazone. you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you. remember that alcohol can add to the drowsiness caused by this drug. plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Metolazone may make your skin sensitive to sunlight. ...
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Side Effects (Source: MedLinePlus)
Frequent urination should go away after you take metolazone for a few weeks. Tell your doctor if any of these symptoms are severe or do not go away: muscle weakness; dizziness; cramps; thirst; stomach pain; upset stomach; vomiting; diarrhea; headache; hair loss. If you experience any of the following symptoms, call your doctor immediately: sore throat with fever; unusual bleeding or bruising; severe skin rash with peeling skin; difficulty breathing or swallowing. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html ] or by phone [1-800-332-1088]. ...
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DrugInfoOnline zaroxolyn

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