Yohimbine readily penetrates the CNS and produces a complex pattern of responses in lower doses than required to produce peripheral alpha-adrenergic blockade. These include, anti-diuresis, a general picture of central excitation including elevation of blood pressure and heart rate , increased motor activity, irritability, and tremor . Sweating , nausea and vomiting are common after parenteral administration of the drug. 1,2 Also dizziness , headache , skin flushing reported when used orally. 1,3
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