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:: Overview :: Precautions :: Side Effects :: Further Reading Search results last updated: 9/17/2008

Generic & Brand Name : Source: (RXList)

Brand Name : Xolair
Generic Name : Omalizumab

Overview (Source: MedicineNet)
Omalizumab is an injectable drug that is used for treating asthma . Omalizumab is a protein that resembles one type of human antibody. Antibodies are proteins produced by the body that recognize foreign substances such as bacteria (that cause infection) and pollens (that cause allergies). Once they recognize a foreign substance, the antibodies attach to receptors on two types of cells in tissues and blood, mast cells and basophils. These cells then release chemicals that cause an allergic reaction that leads to inflammation. Omalizumab blocks the receptors on the surfaces of the mast cells and basophils to which antibodies attach, thereby preventing antibodies from attaching to the cells. As a result, the cells do not release their chemicals, and the allergic reaction and inflammation are prevented. In asthmatic individuals, allergic reactions often cause attacks of asthma. Omalizumab reduces the attacks of asthma by preventing the allergic reactions caused by foreign substances. Omalizumab was approved by the FDA in June, 2003. ...
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Precautions (Source: MedLinePlus)
Before using omalizumab injection, tell your doctor and pharmacist if you are allergic to any medications. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. tell your doctor if you have any other medical conditions and if you are being treated with allergy immunotherapy (allergy shots; a series of injections given regularly to prevent the body from developing allergic reactions to specific substances). tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using omalizumab, call your doctor. talk to your doctor about whether there is a risk that you will develop a hookworm, roundworm, whipworm, or threadworm infection (infection with worms that live inside the body). If you are at high risk of developing this type of infection, using omalizumab may increase the chance that you will actually become infected. Most of these infections are rare in the United States, but if you are at risk of developing an infection, your doctor can suggest ways to prevent infection and will monitor you carefully during your treatment. ...
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Side Effects (Source: MedLinePlus)
Omalizumab injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: pain, redness, swelling, warmth, burning, stinging, bruising, hardness (bump), or itching in the place omalizumab was injected; pain, especially in the joints, arms, or legs; tiredness; ear pain. Omalizumab may increase the risk of developing cancer, including breast, skin, parotid (salivary gland, located near the mouth), and prostate cancer. Talk to your doctor about the risks of using this medication. Omalizumab may cause other side effects. Call your doctor if you have any unusual problems while using this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html ] or by phone [1-800-332-1088]. ...
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RXList Side Effects & Drug Interactions
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Further Reading on xolair

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