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:: Overview :: Precautions :: Side Effects :: Further Reading Search results last updated: 9/17/2008

Generic & Brand Name : Source: (RXList)

Brand Name : Vaniqa
Generic Name : Eflornithine

Overview (Source: MedicineNet)
Eflornithine is the first topical drug for the treatment of unwanted facial and chin hair. It does not remove the hair but rather slows its growth. The cells surrounding the base of each hair (called the hair follicle) undergo rapid growth and maturation as they transform into hairs. Certain proteins called polyamines are needed for this rapid cell growth and differentiation, and the production of these polyamines depends on the activity of an enzyme, ornithine decarboxylase (ODC). Eflornithine is believed to block ODC and thereby slow the growth and differentiation of the cells within the hair follicles. Almost 600 patients were studied who routinely had to remove facial hair at least twice weekly and had more than 5 hairs per square centimeter of skin. The re-growth of hair was evaluated 48 hours after patients shaved before, during, and at the end of treatment. The patients received either eflornithine cream or a placebo cream twice daily for 24 weeks. By the end of 24 weeks of treatment, 70% of eflornithine-treated patients had at least some reduction in the rate of hair growth compared with 41% of placebo-treated patients. Moreover, 35% of eflornithine-treated patients had a marked reduction in the rate of growth (only minimal darkening of facial skin due to re-growth of hair) compared to 9% of placebo-treated patients." Eflornithine was approved by the FDA in July 2000. ...
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Precautions (Source: MedLinePlus)
Before using eflornithine, tell your doctor and pharmacist if you are allergic to eflornithine or any other medications. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. tell your doctor if you have or have ever had severe acne. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using eflornithine, call your doctor. ...
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Side Effects (Source: MedLinePlus)
Eflornithine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: stinging, burning, or tingling of the skin; redness of the skin; skin rash; acne; swollen patches of skin that are reddened and contain a buried hair. Some side effects can be serious. The following symptom is uncommon, but if you experience it, stop using eflornithine and call your doctor immediately: severe irritation of the skin . Eflornithine may cause other side effects. Call your doctor if you have any unusual problems while using this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html ] or by phone [1-800-332-1088]. ...
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Further Reading on vaniqa

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