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:: Overview :: Precautions :: Side Effects :: News :: Further Reading Search results last updated: 9/17/2008

Generic & Brand Name : Source: (MedicineNet)

Brand Name : Nolvadex
Generic Name : tamoxifen

Overview (Source: MedicineNet)
Tamoxifen is an antiestrogen (blocks the effect of estrogen on tissue). The precise mechanism of its action is unknown, but one possible mechanism is that it binds and blocks estrogen receptors on the surface of cells, preventing estrogens from binding and activating the cell. It is used in patients for treating and preventing breast cancer. Controversy currently exists as to which breast cancer patients will benefit from this treatment. ...
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DrugDigestWhat is/are Tamoxifen Oral Solution?
DrugInfoOnlinetamoxifen

Precautions (Source: MedLinePlus)
Before taking tamoxifen, tell your doctor and pharmacist if you are allergic to tamoxifen or any other medications. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aminoglutethimide (Cytadren); anastrazole (Arimidex), bromocriptine (Parlodel); cancer chemotherapy medication such as cyclophosphamide (Cytoxan, Neosar) letrozole (Femara); medroxyprogesterone (Depo-Provera, Provera, in Prempro); phenobarbital; and rifampin (Rifadin, Rimactane). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. in addition to the conditions listed in the IMPORTANT WARNING section, tell your doctor if you have or have ever had high blood levels of cholesterol. tell your doctor if you are pregnant or plan to become pregnant. You should not plan to become pregnant while taking tamoxifen or for 2 months after your treatment. Your doctor may perform a pregnancy test or tell you to begin your treatment during your menstrual period to be sure that you are not pregnant when you begin taking tamoxifen. You will need to use a reliable nonhormonal method of birth control to prevent pregnancy while you are taking tamoxifen and for 2 months after your treatment. Talk to your doctor about the types of birth control that are right for you, and continue to use birth control even if you do not have ...
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DrugDigest What should I watch for while using this medicine?

Side Effects (Source: MedLinePlus)
Tamoxifen may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: increased bone or tumor pain; pain or reddening around the tumor site; hot flashes; nausea; excessive tiredness; dizziness; depression; headache; thinning of hair; weight loss; stomach cramps; constipation; loss of sexual desire or ability (in men). Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately: vision problems; loss of appetite; yellowing of the skin or eyes; unusual bruising or bleeding; fever; blisters; rash; swelling of the eyes, face, lips, tongue, throat, hands, arms, feet, ankles, or lower legs; thirst; muscle weakness; restlessness. Tamoxifen may increase the risk that you will develop other cancers, including liver cancer. Talk to your doctor about this risk. Tamoxifen may increase the risk that you will develop cataracts (clouding of the lens in the eye) that may need to be treated with surgery. Talk to your doctor about this risk. Tamoxifen may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. ...
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DrugDigest What side effects may I notice from this medicine?
DrugInfoOnline tamoxifen

News on tamoxifen
Medco, FDA to study role of genetics in medicine (ReutersHealth)
Relapse may occur years after breast cancer therapy (ReutersHealth)

Further Reading on tamoxifen
  • Fibrocystic Breasts - Treatment Overview ( WebMD )
    Most women who have fibrocystic breast changes or cyclic breast pain do not require treatment from their health professional ...pain, with fewer side effects than tamoxifen . 3 Goserelin injections...
  • Breast Cancer - Treatment Overview ( WebMD )
    Breast cancer is usually treated with surgery, medications, and radiation therapy...and can destroy cancer cells outside the target area. Hormone therapy with tamoxifen or an aromatase inhibitor, to...
  • Cancer Genetics Overview (PDQ®) - Introduction ( WebMD )
    Many of the medical and scientific terms used in this summary are found in the NCI Dictionary of Genetics Terms . When a linked ...specific interventions aimed at reducing risk (e.g., tamoxifen for...
  • Cancer Prevention Overview (PDQ®) - Cancer Prevention ( WebMD )
    The summaries in the cancer prevention section of PDQ address the prevention of specific types of cancer . Prevention is defined as ...use of selective estrogen receptor modulators ( tamoxifen or...
  • Breast Pain (Mastalgia) - Topic Overview ( WebMD )
    What do I need to know about breast pain ? Many women have breast tenderness and pain , also called mastalgia . It may come and go ...risk of Reye's syndrome. Danazol, bromocriptine, and tamoxifen citrate...


  • Nonalcoholic Steatohepatitis (NASH) - Overview ( WebMD )
    What is nonalcoholic steatohepatitis ( NASH )? Nonalcoholic steatohepatitis ( NASH ) is liver inflammation caused by a buildup of fat ...glucocorticoids, synthetic estrogens, and tamoxifen . What are the...
  • Cancer Genetics Overview (PDQ®) - Structure and Content of PDQ Summaries ( WebMD )
    PDQ cancer genetics summaries focus on the genetics of specific cancers , inherited cancer syndromes , and the ethical , social , and ...before cancer develops, and use of medications (e.g., tamoxifen for...
  • Breast Cancer Treatment (PDQ®) - Stage I,II,IIIA,and Operable IIIC Breast Cancer ( WebMD )
    Note : Some citations in the text of this section are followed by a level of evidence . The PDQ editorial boards use a formal ...predicting response to adjuvant endocrine therapy.[81] Tamoxifen The...

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