samarium SM-153/lexidronam-injection, Quadramet

:: Overview :: Precautions :: Side Effects

Search results last updated: 9/16/2008

Generic & Brand Name : Source: (RXList)

Brand Name : Quadramet
Generic Name : Samarium SM 153 Lexidronam

Overview (Source: MedicineNet)

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Precautions (Source: RXList)

EDTMP is a chelating agent. Although the chelating effects have not been evaluated thoroughly in humans, dogs that received non-radioactive samarium EDTMP (6 times the human dose based on body weight, 3 times based on surface area) developed a variety of electrocardiographic ( ECG ) changes (with or without the presence of hypocalcemia ). The causal relationship between the hypocalcemia and ECG changes has not been studied. Whether Quadramet causes electrocardiographic changes or arrhythmias in humans has not been studied. Caution and appropriate monitoring should be given when administering Quadramet to patients. ... [ read more.. ]

Side Effects (Source: RXList)

The potential for additive bone marrow toxicity of Quadramet with chemotherapy or external beam radiation has not been studied. Quadramet should not be given concurrently with chemotherapy or external beam radiation therapy unless the benefit outweighs the risks. Quadramet should not be given after either of these treatments until there has been time for adequate marrow recovery. (See Warnings Section). ...
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quadramet : Drugs Search Results from the Invisible Web