In addition to Naloxone Hydrochloride Injection, other resuscitative measures, such as maintenance of a free airway , artificial ventilation , cardiac massage and vasopressor agents should be available and employed, when necessary, to counteract acute narcotic poisoning . Several instances of hypotension , hypertension , ventricular tachycardia and fibrillation , and pulmonary edema have been reported. These have occurred in postoperative patients most of whom had pre-existing cardiovascular disorders or received other drugs which may have similar adverse cardiovascular effects. Although a direct cause and effect relationship has not been established, Naloxone Hydrochloride Injection should be used with caution in patients with pre-existing cardiac disease or patients who have received potentially cardiotoxic drugs.
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