General: The recommended dosage for chemoprophylaxis of malaria should not be exceeded. A small "starting" dose for toxoplasmosis is recommended in patients with convulsive disorders to avoid the potential nervous system toxicity of pyrimethamine. DARAPRIM should be used with caution in patients with impaired renal or hepatic function or in patients with possible folate deficiency, such as individuals with malabsorption syndrome , alcoholism , or pregnancy , and those receiving therapy , such as phenytoin, affecting folate levels (see Pregnancy subsection).
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