General FRAGMIN Injection should not be mixed with other injections or infusions unless specific compatibility data are available that support such mixing. FRAGMIN should be used with caution in patients with bleeding diathesis , thrombocytopenia or platelet defects; severe liver or kidney insufficiency, hypertensive or diabetic retinopathy , and recent gastrointestinal bleeding. If a thromboembolic event should occur despite dalteparin prophylaxis , FRAGMIN should be discontinued and appropriate therapy initiated.
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