Sulfonamide (sul-FON-ah-mide) and trimethoprim combinations are used to prevent and treat infections. Sulfadiazine and trimethoprim combination is used to treat urinary tract infections. Sulfamethoxazole and trimethoprim combination is used to treat infections, such as bronchitis, middle ear infection, urinary tract infection, and traveler's diarrhea. It is also used for the prevention and treatment of
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